The aircraft, which was assigned to the 480th Fighter Squadron from Spangdahlem Air Base, Germany, met with the accident during a training flight at US Army Garrison Bavaria in Grafenwoehr.
The F-16 pilot was able to successfully eject from the aircraft and also managed to jettison the fuel tanks over an unpopulated area.
52nd FW vice commander colonel Steve Horton said: "Our pilots go through extensive emergency procedure training, preparing them for a variety of crises that may occur in the air and on the ground.
"Our pilots are very familiar with their aircraft and how to egress from them safely in the event of an emergency. We are thankful that our pilot was able to put his training into action."
The USAF revealed that the aircraft was carrying six 25lb training munitions, but there were no live munitions on board.
Currently, the US military first responders are working with German authorities to secure the crash site.
A statement from the Spangdahlem Air Base said that the cause of the accident is currently under investigation.
In June, an Iraqi Air Force’s F-16 fighter jet crashed in Arizona near the US-Mexico border during a night training mission.
The accident involved an Iraqi student pilot, who was on a training programme in Tucson by the Arizona Air National Guard’s 162nd Wing.
Image: A USAF F-16 Fighting Falcon takes off from the flightline at Spangdahlem Air Base, Germany. Photo: courtesy of U.S. Air Force photo by Staff Sgt. Joe W. McFadden/Released.